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Silencing immune attacks in type 1 diabetes
Could diabetes be treated without insulin shots? (Tess Watson/Flickr) For decades, patients have managed their type 1 diabetes by injecting themselves with insulin to regulate the glucose in their...
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Deconstructed ‘death receptors’ suggest new ways to tackle cancer, autoimmune...
The 3-D structure of the Fas death receptor’s transmembrane region, consisting of three tightly packed helices shown here from three angles. Cancer-causing mutations deform this structure, preventing...
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Transfusing engineered red blood cells to protect against autoimmune disease
Transfusions of engineered red blood cells could help prevent and/or treat autoimmune disease. Autoimmune disease is usually treated using general immunosuppressants. But this non-targeted therapy...
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Finding what fuels the “runaway train” of autoimmune diseases
Natural selection on a small scale: Immune cells called B cells battle each other to produce the best antibody. Here, green represents the B cells that are producing the “winning” antibody, which stamp...
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Immune gene guards against type 1 diabetes by changing the microbiome. Do...
The health of our immune system is increasingly linked with the health of our intestinal bacteria. A mouse study from Harvard Medical School now hammers this home for autoimmune disorders, in which...
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Science and medicine in 2018: What’s the forecast?
Vector consulted its many informants to find out which way the wind will blow in 2018. Here are their predictions for what to expect in genetics, stem cell research, immunology and more. GENETICS...
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Link found between chronic inflammation, autoimmune disorders and “false alarms”
Viruses have a genetic signature that a human receptor called MDA5 recognizes, causing the immune system to attack. But when MDA5 confuses the body’s own genetic material for that of a virus, disease...
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This autoimmune awareness month, meet Boston scientists who are pushing the...
In a mouse model of lupus, colorized red and green B cells outdo their blue, yellow and aqua competitors. Each color represents a different B cell clone. The proliferation of red and green B cells...
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Skewed T-cell pathway may help explain transplant rejection, autoimmune diseases
Researchers discover a pathway that controls our T helper cell profiles (Fawn Gracey illustration) Second in a two-part series on transplant tolerance. (See part one.) Our immune system has two major...
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